In the comparison of obese individuals before RYGB with non-obese Controls, IPA predicted multiple interactions between miRNAs and molecules required for miRNA biogenesis (AGO2 and DICER1) and those implicated in CRC development (DELTA133P53, CCNE1 and STAT3) (Fig. 1D). This evidence concerns the gene DICER1 and colorectal carcinoma.