In the comparison of obese individuals before RYGB with non-obese Controls, IPA predicted multiple interactions between miRNAs and molecules required for miRNA biogenesis (AGO2 and DICER1) and those implicated in CRC development (DELTA133P53, CCNE1 and STAT3) (Fig. 1D). The gene discussed is AGO2; the disease is colorectal carcinoma.