Previously, we demonstrated that the Hsp70 chaperone uses distinct mechanisms to penetrate cells; a major way in human neuroblastoma SK-N-SH and rat glioma C6 cells was endocytosis, whereas in human erythroleukemia cells, K562, Hsp70 entered mainly using lipid rafts18,24. The gene discussed is HSPA1A; the disease is neuroblastoma.