AKR1B1 and acute myeloid leukemia: Meta-analysis of SNPs common to all four GWAS (N = 6661818 and N = 6496414 for all AML and cytogenetically normal AML, respectively) also revealed additional borderline significant susceptibility loci at 1p31.1 (rs10789158, CACHD1, P = 2.25 × 10−7) for all AML and at 7q33 (rs17773014, AKR1B1, P = 4.09 × 10−7) for cytogenetically normal AML, both with consistent direction and magnitude of effect across all four studies (Figs. 1 and 2).