HLA-DQB1*03:02 (r2 = 0.56 with rs3916765) was significantly under-represented in AML cases compared to controls in meta-analysis (OR 0.63, 95% CI 0.51–0.72, P = 8.9 × 10−8), identifying this as the most likely classical HLA allele underpinning the association with AML at the 6p21.32 locus (Supplementary Fig. 22). The gene discussed is HLA-DQB1; the disease is acute myeloid leukemia.