Unlike normal monocytes, AML cells can also utilize fructose as an alternative substrate for glycolysis with expression of the GLUT5 fructose transporter as a major regulator of fructose metabolism in leukemic blast cells51,52, and where high expression is associated with increased proliferation, clonogenicity, migration, and invasion of AML cells51. Here, SLC2A5 is linked to acute myeloid leukemia.