We identified a genome-wide significant association for rs4930561 with risk of AML irrespective of sub-type (OR 1.17, 95% CI 1.11–1.24; P = 2.15 × 10−8) which maps to the KMT5B gene on 11q13.2 (Fig. 3a). The gene discussed is KMT5B; the disease is acute myeloid leukemia.