We also identified a borderline significant association for rs10789158 with AML irrespective of sub-type (OR 1.22, 95% CI 1.13–1.31; P = 2.25 × 10−7) which maps to a block of linkage disequilibrium upstream of the CACHD1 gene on chromosome 1p31.3 (Fig. 3c). Here, CACHD1 is linked to acute myeloid leukemia.