Fluid shear stress increased IL-6 release in renal cells cultured with media alone (632 ± 36 ng/mL rotating vs. 478 ± 52 ng/mL static, p = 0.036, W = 34, n1 = 7, n2 = 6,) and with myeloma light chains from donor B (Fig. 9b, 772 ± 19 ng/mL rotating vs. 630 ± 30 ng/mL static, p = 0.001, W = 41, n1 = 7, n2 = 6), but not myeloma light chains from donor C (1055 ± 44 ng/mL rotating vs. 1040 ± 109 ng/mL static). The gene discussed is IL6; the disease is plasma cell myeloma.