Similarly, in our study, PSMC2 was closely associated with the pathological stages and lymphatic metastasis (N) of SKCM patients, and that PSMC2 expression was ubiquitously expressed in SKCM samples than in the adjacent para-cancer skin tissues, and overexpressed SKCM cell lines, as A375, SK-MEL-1, and SK-MEL-28 than PIG1 cell line. Here, PSMC2 is linked to cancer.