Although we could not provide the evidence about NLRP3 in clinical biopsy specimens from AKI-progressed CKD, we also found NLRP3 increasing associated with renal tubular lesions by immunofluorescence of other CKD biopsies e.g., DN, IgAN, LN, and FSGS. The gene discussed is NLRP3; the disease is liver dysplastic nodule.