ZNRF3 and neoplasm: ZNRF3 loss was not significantly associated with ETS fusion status (Supplementary Data 6), chromothripsis (p = 0.208, Fisher’s Exact test), kataegis (q = 0.298, Fisher’s Exact test), global SNV burden (p = 0.376, Mann–Whitney U test), or tumor hypoxia, measured either using a consensus RNA abundance surrogate signature43 (p = 0.518, Mann–Whitney U Test) or by direct intratumoral oxygen measurements32,44 (p = 0.550, Mann–Whitney U Test).