Furthermore, our results are consistent with two recent phase 3 clinical trials that found the CRTH2 antagonist fevipiprant did not reduce the rate of asthma exacerbations requiring systemic corticosteroids in patients with severe asthma, including a subgroup with raised blood eosinophils indicative of ongoing type 2 inflammation.30 Our study highlights that controlled experimental RV challenge studies can be used to study the effects of novel therapies using smaller numbers of patients and provide results that are consistent with larger scale trials. The gene discussed is PTGDR2; the disease is asthma.