CFAP45 and ciliopathy: CFAP45 has been recently published as a motile ciliopathy gene,35 so it is possible that the homozygous nonsense CFAP45 variant present in participant #48 but not their sibling could account for the clinical motile ciliopathy features in participant #48, with the LRRC45 variants accounting for the neurodevelopmental delay and intellectual disability in both siblings.