PRCC and hepatocellular carcinoma: A nude mouse model was used by cell injection through tail vein to verify the effect of PRCC on metastasis and tumorigenicity of HCC cells, and the results showed no significant difference in mouse body weight among the Hep3B, Hep3B-EGFP and Hep3B-PRCC OE groups, but the size and numbers of tumors in mouse lung tissues in the Hep3B group and Hep3B-EGFP group were significantly higher than that in the Hep3B-PRCC OE group, and the difference was statistically significant (P < 0.05) (Fig. 4e–g).