MALAT1 and colorectal carcinoma: Mechanistically, KDM4C overexpression in colorectal tumor tissues and metastatic samples can lower H3K36me3 and H3K9me3 levels at MALAT1 promotors, thereby upregulating MALAT1 expression and enhancing β-catenin signaling pathway strength, conferring tremendous metastatic potential for CRC cells [97].