Although there are few studies on the association between SETD2/H3K36me3 and cell signaling pathways in cancers, given the above-referred studies of SETD2/H3K36me3 in ccRCC, at least the correlation between SETD2 and Wnt/β-catenin signaling pathway regulatory network is defined to some extent. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.