Since the initial association between KLK8 DNAm levels and depression phenotypes was discovered not for the depression ICD-10 diagnosis but for severity of depression symptoms, we first evaluated association between DNAm levels at CpG1 and CpG2 with the 20 SCAN variables for depression symptomatology (Materials and Methods: ii). Here, KLK8 is linked to spinocerebellar ataxia, autosomal recessive, with axonal neuropathy.