PRTN3 and rheumatoid arthritis: After applying the 36-marker mass cytometry (MC) panel to 15 untreated, early ACPA+ and ACPA− RA patients (Table 1), we first performed a 5-level HSNE dimension reduction on all 15 samples simultaneously, showing a clear separation of different major immune lineages such as T cells, B cells and monocytes (Fig. 1A, B, dashed lines).