TANGO2 and epilepsy: TANGO2 mutations at 22q11.2 have been associated with metabolic abnormalities such as hypoglycemia, as well as epilepsy, and our PheWAS for TANGO2 showed abnormal glucose (P = 0.0013) and epilepsy, recurrent seizures, and convulsions (P = 0.0049) as top phenotypes [95, 96].