Moreover, three novel brain-related gene-trait pairs reached phenome-wide significance: NPIPB11 and SLX1B near the CNV breakpoint at 16p11.2 with psychosis, as well as SCARF2 at 22q11.2 with mood disorders. The expression of SLX1B is modified in 16p11.2 carriers; NPIPB11 expression differences have not been detected in transcriptomic studies of 16p11.2 [43, 45]. Here, NPIPB11 is linked to psychotic disorder.