TBX1, a gene at 22q11.2 tied to heart development, had other chronic ischemic heart disease, unspecified (P = 0.001), endocarditis (P = 0.0046), cardiomyopathy (P = 0.0055), and coronary atherosclerosis (P = 0.0076) among its top 1% phenome associations [28–31]. The gene discussed is TBX1; the disease is endocarditis.