Of the genes that we found as drivers in the first analysis of GWAS datasets, we note that INO80E’s top PheWAS results overlap the 16p11.2 deletion-associated trait other specified cardiac dysrhythmias and SPN’s top PheWAS results overlap the 16p11.2 duplication-associated trait of failure to thrive (childhood). The gene discussed is SPN; the disease is Failure to thrive.