There were eleven phenome-wide significant gene-trait associations at 22q11.2 including as follows: AIFM3 with renal failure (P = 2.3 × 10−5), LZTR1 with malignant neoplasm, other (P = 1.4 × 10−5), SCARF2 with mood disorders (P = 1.3 × 10−5), PI4KA with disorders of iris and ciliary body (P = 1.1 × 10−7), and disorders resulting from impaired renal function (P = 2.2 × 10−5). Here, AIFM3 is linked to cancer.