Up to date, TLR2, TLR3, TLR4, TLR7, and TLR9 have been intensely studied in glioma, while less or missing information is available regarding the mechanisms of TLR1/TLR6 (dimerizes with TLR2), TLR5, TLR8 (dimerizes with TLR7), and particularly TLR10. This evidence concerns the gene TLR6 and central nervous system cancer.