TLR2 and neoplasm: Activation of TLR1/2 heterodimers and TLR2/6 heterodimers in GAMs plays an important role in extracellular matrix remodeling and tumor expansion through induction of matrix metalloproteinases (MMPs), interleukin (IL)-6, and inducible nitric oxide synthase (iNOS) [62, 75–77].