PLA2G16 (Group XVI phospholipase A2), also known as PLAAT3, H-REV-107, HRASLS3 (Ha-RAS-like suppressor 3), and AdPLA2 (adipose-specific PLA2), was first considered as a tumor suppressor by inhibiting Ras-mediated transformation in H-RAS-resistant murine fibroblasts [18]. The gene discussed is PLAAT3; the disease is neoplasm.