For instance, miR-422a was confirmed to inhibit glioma cell proliferation, invasion, and migration by targeting PIK3CA, which is a critical member of PI3K/Akt signal pathway [18]; miR-422a was proven to directly target AKT1 to inhibit PI3K/Akt pathway and colorectal cancer cell proliferation [19]. This evidence concerns the gene AKT1 and glioma.