TILs and TAMs have anti-inflammatory phenotypes and either secrete or induce factors that promote immunosuppression and tumor invasion, such as interleukin-10 (Il-10), TGF-β, PD-1, reactive oxygen species (ROS) and arginase [40, 43, 49, 65, 76–80] (Fig. 2). The gene discussed is PDCD1; the disease is neoplasm.