ALB and Epstein-Barr virus infection: In univariate logistic regression analysis, lower CR rate was related to first diagnosis older than 60 years, IPI ≥ 3, ECOG ≥ 3, stage III-IV, B symptoms, bone marrow involvement, Albumin < 35 g/L, EBV infection, Extra-nodal > 1, lymphocyte (LY)(× 109/L) < 0.8, monocyte (MONO)(× 109/L) > 1, platelet (PLT)(× 109/L) < 83, elevated LDH and elevated β2-MG, LMR ≤ 1.68 and PMR ≤ 300 (Table 2).