RHOA and glioblastoma: The GSEA analysis of all upregulated GBM (primary and recurrent) genes putatively modified by SUMO2/3, showed enrichment for major pro-tumourigenic processes such as invasion, metastasis, proliferation, stemness, EMT, drug resistance, hypoxia, plasticity, downregulation of senescence, adipogenesis, upregulation of protumourigenic genes associated with HOX, Myc, MLL, HNFIA, NPM1, KRT19 and RhoA and enrichment of inflammatory stromal and microglial cells (Fig. 1G and Additional file 4: Table S17).