The protein expression of the heparan sulfate proteoglycan, syndecan-1, is significantly higher in the non-affected skin samples from patients with psoriasis than skin tissue collected from psoriasis plaque 173.08 ± 7.93 ou/μm2 versus 150.34 ± 17.44 ou/μm2 (p = 0.0093). This evidence concerns the gene CD44 and psoriasis.