The significant increase in the expression of heparanase-1 (HPSE), heparanase-2 (HPSE2), syndecan-1 (SYND1), metalloproteinase-9 (MMP9), and tissue inhibitor of metalloproteinase 2 (TIMP2) in biopsies of skin affected by psoriasis showed extracellular matrix alterations in psoriasis. This evidence concerns the gene HPSE and psoriasis.