The labeling of heparanase-1 (HPSE) in the psoriasis plaque was greater than in the control skin 160.16 ± 11.89 ou/μm2 versus 125.58 ± 20.56 ou/μm2 (p < 0.0001), as shown in Fig. 2. This evidence concerns the gene HPSE and psoriasis.