AKT1 and cancer: As for the expression loss of ARID1A, multiple studies had verified that the loss of ARID1A expression was also related to the alterations of genes belongs to PI3K/Akt signaling pathway (Bosse et al. 2013; Huang et al. 2014) and alternate the biological behaviors of tumor cells via this signaling pathway in variety of cancer types (Wiegand et al. 2014; Yang et al. 2019).