Alterations in ARID1A may be diverse and have been observed in a variety of cancer types, including urothelial carcinoma (Dugas et al. 2019), gastric cancer (Kim et al. 2019) and lung cancer (Huang et al. 2015; Naito et al. 2019) and the variants of ARID1A gene could also be detected through liquid biopsy even for cancers of unknown primary (Laprovitera et al. 2021) as well. This evidence concerns the gene ARID1A and cancer.