Genetic under-sulfation of heparan sulfate on a unique class of myeloid-derived CD11c+ antigen presenting cells results in an innate cellular immune profile characterized by reductions in tumor-infiltrating suppressive FOXP3+ cells and CD163+ M2-type tumor-permissive macrophages during early bronchocentric adenoma formation in a Kras-mutant spontaneous lung tumor model. The gene discussed is ITGAX; the disease is neoplasm.