CD8A and neoplasm: Unlike our more advanced model of macroscopic Lewis Lung carcinoma tumors (LLCs) on the mutant background, where CD8+ effector T cell infiltration is driven, and where tumor antigen load differences may be more advanced (driving acquired anti-tumor immunity), we did not note up-regulation of CD8+ T cells into the early tumors (Fig. 2A); instead, we found a phenotype in the formation of early tumor micro-nodules (Fig. 1B) and an effect on Treg infiltration (Tregs per unit tumor mass; Fig. 2B).