Spontaneous Kras-mutant lung carcinoma model demonstrates a lower frequency of early tumor foci in a setting of HS-altered APCs. We generated an inducible model of Kras driven lung cancer, CCSP-rtTA; (tetO7) CMV-Kras-G12D [7] in the setting of mutation in a unique glycan sulfating biosynthetic enzyme. Here, KRAS is linked to lung cancer.