FOXP3 and neoplasm: A similar reduction was noted upon indexing densities to the estimated mean tumor volume per nodule (to more strictly control for any effects of tumor size; P = 0.08 for difference in tumor volume indexed means in Fig. 2C): The reduction in FOXP3+ cell density indexed for tumor mass showed essentially the same trend, indicating what appears to be a distinct inhibitory effect of mutation on the unique tendency of FOXP3+ cells to associate or infiltrate the parenchyma of the early Kras tumors on the wildtype background.