PBRM1 and nonpapillary renal cell carcinoma: Finally, an association between mutations in PBRM1, present in ∼60% of ccRCC, and response to CPI has been reported (Braun et al., 2019, 2020; Miao et al., 2018), though the association has not been observed consistently (McDermott et al., 2018; Motzer et al., 2019, 2020a; Motzer et al., 2019, Abou Alaiwi et al., 2020; Motzer et al., 2020a).