Those in the RBS arm also receive genomic screening for nine high and moderate penetrance breast cancer genes (ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, STK11, and TP53), and >200 single nucleotide polymorphisms (SNPs) associated with breast cancer risk. The gene discussed is PALB2; the disease is breast carcinoma.