In this study, we sought to understand the relationship between surface impedance values of muscle obtained in vivo and impedance values obtained ex vivo in an impedance-measuring cell in three different murine models of neuromuscular disease: the mouse ALS SOD1 G93A model [23], the D2-mdx model of Duchenne muscular dystrophy [24], and the diabetic obese db/db mouse model [25], in which muscle atrophy without primary muscle disease is present. Here, SOD1 is linked to amyotrophic lateral sclerosis.