We found that 6 mRNA expressions were significantly different (P<0.05), including GBP6 (guanylate binding protein), TMEM (transmembrane protein), CTCFL (liver cancer marker gene), KRT5 (keratin 5), LY6D (lymphocyte antigen) and TMEM179 (transmembrane protein). The gene discussed is GBP6; the disease is liver cancer.