In mice, genomic deletion of the mammalian Indy homolog (mIndy), as well as liver-specific mINDY depletion, results in a protection against obesity, fatty liver, and insulin resistance upon feeding a high-fat diet—metabolic conditions comparable to those observed in flies and worms [21–23]. The gene discussed is SLC13A5; the disease is obesity due to melanocortin 4 receptor deficiency.