Molecular aberrations that were shared in at least one P/X pair and that were previously recognized to have deleterious effects in human cancers included CHEK2 [K416E; 415S (SNP)] [23, 24], EGFR (158N) [25], ATM (P1054R) [26], STK11 (D194N) [27], PIK3CA (E545K) [28], KIT (798I; M541L) [29, 30], and RUNX1 (L56S) [31]. This evidence concerns the gene PIK3CA and cancer.