Given the important role of Estrogens in repressing HSCs activation and liver fibrosis by interacting with its nuclear receptors (ER-α, and ER-β) and membrane receptor (G protein-coupled estrogen receptor, GPER1) [31], we next investigated whether SSd exerted its anti-liver fibrotic function by regulating estrogen receptors expression. The gene discussed is ESR1; the disease is Hepatic fibrosis.