GPER1 and Hepatic fibrosis: In this study, we found that (I) SSd alleviated hepatic fibrosis and repressed autophagy activation in CCl4-treated mice; (II) SSd repressed CCl4-induced autophagy activation of HSCs in vivo; (III) SSd repressed HSCs autophagy activation by regulating GPER1; (IV) SSd alleviated liver fibrosis through regulating GPER1/autophagy pathway.