Thus, this present study has tried to explore the gene network analysis through STRING database with 382 genes involved in NSHL at high confidence score and identified the highly interacted HL target genes UBC, HGF, CDH23, RAC1, SOX2, MYO7A, and PCDH15 in each of the four biological processes groups have been chosen as gene hub in the NSHL target gene panels. Here, SOX2 is linked to nodular sclerosis classical Hodgkin lymphoma.