Some of the pathogenic (Arg798X, Gly829X, Leu391Arg, Glu747X, Arg425X, Tyr474X, Trp717X, Tyr1064X, Gln1072X, Arg1856Gln, Arg1172Gln) and likely pathogenic (Pro489Ser, His513Arg, Arg1583His, Arg1792Cys, Arg1792His) variants in OTOF have been reported in autosomal recessive NSHL cases of Texas, Qatar, and Japan populations [9,39,40]. Here, OTOF is linked to nodular sclerosis classical Hodgkin lymphoma.