But only the nsSNPs rs80356586 (Ile515Thr), rs80356596 (Leu1011Pro), rs80356606 (Pro1987Arg) found in OTOF have been reported particularly in NSHL conditions, whereas the nsSNPs rs121909642 (Pro722Ser) of FGFR1 has reported in hypogonadotropic hypogonadism 2 with anosmia, but rs267606805 (Pro722His) has not reported in any disease condition. The gene discussed is FGFR1; the disease is hypogonadotropic hypogonadism.