In this study, the most deleterious nsSNPs rs80356586 (Ile515Thr) [44], rs80356596 (Leu1011Pro) [45,46], rs80356606 (Pro1987Arg) [47] found in OTOF gene were reported in UniProt and ClinVar datasets for NSHL cases. The gene discussed is OTOF; the disease is nodular sclerosis classical Hodgkin lymphoma.