Thus, this present study has tried to explore the gene network analysis through STRING database with 382 genes involved in NSHL at high confidence score and identified the highly interacted HL target genes UBC, HGF, CDH23, RAC1, SOX2, MYO7A, and PCDH15 in each of the four biological processes groups have been chosen as gene hub in the NSHL target gene panels. This evidence concerns the gene RAC1 and nodular sclerosis classical Hodgkin lymphoma.