CD4 and AIDS: 2003; Hou et al. 2018; Yu et al. 2019; Lu et al. 2020). We found that Cortex Mori significantly inhibited the activity of HIV-1 RT enzyme, thus blocking the replication of the virus. In anti-HIV experiments in vitro, Shi de Luo et al. (1995) found that 50 types of Chinese medicines, including Cortex Mori, had anti-HIV effects. Cortex Mori is also one of the components of ‘Compound SH’ (An anti-HIV compound of TCM) (Cheng et al. 2015). A clinical study showed that the decline in CD4 cell count was slowed and reversed in AIDS patients taking oral compound SH (Kusum et al. 2004).