[42–45] LDL has been reported as a risk factor in the context of cancer progression and metastases.[46] Moreover, it was reported by Kumar et al. that high levels of LDL are linked to BC.[47] Increased BC proliferation and metastasis was observed following LDL stimulation, as the levels of tumor LDL receptors increased.[48] However, it was demonstrated that BC patients with metastases had a significantly lower level of LDL compared with a control group.[49] This may be because of the large consumption of LDL during rapid proliferation and metastases in BC. The gene discussed is LDLR; the disease is cancer.