Although there are a wealth of drugs and methods for the treatment of diabetes, there are various insulin and oral hypoglycemic agents, such as biguanides, thiazolidinediones, α-glycosidase inhibitors, sodium-glucose cotransporter 2 inhibitors, sulfonylureas, glinide, and dipeptidyl peptidase IV inhibitors, that can effectively lower blood sugar in a short time, eliminate clinical symptoms, and delay the occurrence of complications. The gene discussed is INS; the disease is diabetes mellitus.