Besides, increased levels of Icam‐1 and Vcam‐1 as well as Cxcl5 further point to endothelial activation after 16 h. These data were corroborated by plasma NGAL‐ELISAs and urea measurements demonstrating AKI 4 h after TxT‐sEV injection (Figure 8f). This evidence concerns the gene LCN2 and acute kidney injury.