The aim of this study was to evaluate the relationship between the number of vaso-occlusive events in SCD, plasma concentrations of the pro-inflammatory molecules 12-HETE, TNF-α, and IL-1β, and the SNPs rs2073438 and rs1126667 (Gln261Arg) in ALOX12 gene which encodes the enzyme 12-Lipooxygenase that catalyses the biosynthesis of 12-HETE. The gene discussed is ALOX12; the disease is Schnyder corneal dystrophy.