ALOX12 and Schnyder corneal dystrophy: The effects of these two ALOX12 SNPs on plasma 12-HETE and the number of vaso-occlusive events in SCD were evaluated because rs2073438 had been associated with high urinary concentration of 12-HETE in a previous study (Quintana et al., 2006); and rs1126667 is one of the only two common missense SNPS in ALOX12 (and so could plausibly affect the function of the gene’s protein product 12-lipooxygenase which catalyses 12-HETE synthesis); the other is rs434473 (Witola et al., 2014).