Additionally, an allele-specific editing strategy based on AAV-mediated delivery of the KKH SaCas9 variant has been recently designed to target a point mutation in the Tmc1 gene, which is responsible for hair cell degeneration and progressive hearing loss in the Beethoven mouse, a model for DFNA36 hearing loss in humans (Gyorgy et al., 2019). This evidence concerns the gene TMC1 and hearing loss disorder.