CSF3 and sickle cell disease: Unfortunately, because in certain cases, such as in the case of sickle cell disease, patients mobilize poorly or due to innate characteristics of the disease per se use of granulocyte colony stimulating factor (G-CSF) is not recommended, one of the first challenges toward clinical translation would be the existence of a validated freezing protocol followed by a validated thawing protocol as it is possible that certain patients would need to undergo multiple rounds of mobilization.