DNMT1 and hemoglobinopathy: In addition, recent work identified a DNMT1 germline missense mutation giving rise to HPFH (Gong et al., 2021), thus providing direct evidence for DNMT1 as a key γ-globin epigenetic co-repressor and further validating it as a therapeutic target for hemoglobinopathies (Saunthararajah, 2021).