SBDS and acute myeloid leukemia: Hematopoietic cell specific deletion of Sbds did not result in MDS or AML in two murine disease models (Rawls et al., 2007; Zambetti et al., 2015), whereas exposure of wildtype HSCs to Sbds-deficient osteolineage MSCs led to an MDS phenotype and genotoxic stress in HSCs (Zambetti et al., 2016).