However, Nestin+ cells, as well-documented MSCs in the BM (Mendez-Ferrer et al., 2010), have been shown to be 4–5-fold more abundant in human AML patients, in line with expansion of Nestin+ cells in the murine iMLL-AF9 AML model (Hanoun et al., 2014; Forte et al., 2020). The gene discussed is NES; the disease is acute myeloid leukemia.