Concerning the HBB mutation-specific gene editing strategies for hemoglobinopathies, these have hitherto mostly targeted mutations that create cryptic splice sites that, via aberrant splicing and ensuing coding sequence frameshifts, cause β-thalassemia (Patsali et al., 2019b; Xu et al., 2019). The gene discussed is HBB; the disease is hemoglobinopathy.