Evidence that support this hypothesis is the inconsistent penetrance of leukemia in GATA2 haploinsufficiency patients that cannot be explained solely by the mutations in the GATA2 locus and MDS/AML patients with germline GATA2 mutation presented with additional mutations which are linked to hematological malignancies (Wlodarski et al., 2016; Fisher et al., 2017; Yoshida et al., 2020). The gene discussed is GATA2; the disease is leukemia.