Prior to our discovery of hemozoin in SLC48A1-deficient RES macrophages, hemozoin had only been observed in the lysosomal-like organelles of blood-feeding organisms that digest hemoglobin such as malaria parasites of the genus Plasmodium (Francis et al., 1997; Egan, 2008; Pek et al., 2019). This evidence concerns the gene SLC48A1 and malaria.