This revealed that knockdown of several components of the endosomal sorting complexes required for transport (ESCRT) machinery, including charged multivesicular body protein 6 (CHMP6), or CHMP2A in combination with CHMP2B (whose gene is linked to familial fronto-temporal dementia), promote propagation of τ aggregation. The gene discussed is CHMP6; the disease is frontotemporal dementia.