In addition, interactome analysis revealed that the INPP5D gene encoding Src homology 2 (SH2) domain, containing inositol polyphosphate 5-phosphatase 1 and CD2AP gene encoding CD2-associated protein, which are known as genetic AD risk factors, were mapped in the same protein-protein interaction network with genes that were identified by the screening. This evidence concerns the gene CD2AP and Alzheimer disease.