HNF4A and metabolic dysfunction-associated steatotic liver disease: In addition to the well-established regulation of LDLR activation by SREBFs and HNF4A, YY1 and KLF13, two specific TFs regulating the disease-associated modules, also showed a regulatory role in the transcriptional regulation of LDLR. Taken together, the complicated regulation of LDLR in the disease-associated modules rather than endocytosis in normal liver tissue might play an essential role in the dysregulation of lipid metabolism underlying the NAFLD pathogenesis.