Thus, our study aims to explore the carriage of HLA-DRB1*11 and HLA-DRB1*12 alleles in a Burkinabe population with unselected breast cancer (sporadic or family history/hereditary cases) to determine possible associations between HLA-DRB1*11 and HLA-DRB1*12 alleles and the susceptibility to breast cancer occurrence. Here, HLA-DRB1 is linked to breast carcinoma.