Toyoshima et al. [22] reported that high levels of IL-6 can interfere with type-I IFN signals in the immune system and is accompanied by low expression of major histocompatibility complex class I (MHC I) molecules, which can then weaken the antitumor effect of CD3+CD8+ T cells and promote tumor growth, development, and distant colonization. Here, CD8A is linked to neoplasm.