A high level of IL-10 has an immunosuppressive effect that facilitates the immune escape of cancer cells, but IL-10 also has an antitumor effect by increasing the infiltration of CD3+CD8+ T cells and the production of IFN-γ in tissues, which may be related to the fact that IL-10 targets different cells (myeloid and T cells) in different cancers or that T cells respond differently to IL-10 at different effective stages [23]. The gene discussed is CD8A; the disease is cancer.