The mechanism may be that tumor cells or necrotic surrounding tissues trigger the release of tissue factors, which activate coagulation factors X and XI in the extrinsic coagulation system and fibrinolytic system, leading to the local production of fibrinolytic enzymes, which can directly degrade the extracellular matrix and endow the tumor cells with the invading and metastatic abilities [26]. Here, F10 is linked to neoplasm.