Since AKT/mTOR and ERK/mTOR pathways were significantly affected after the downregulation of PRMT5 in AML cell lines, we speculated that PRMT5 might affect the expression of LILRB4 and the invasive capability of AML cells through AKT/mTOR and ERK/mTOR axes. The gene discussed is PRMT5; the disease is acute myeloid leukemia.