PRMT5 and acute myeloid leukemia: Firstly, the clinical samples from 30 AML-M5 patients were examined, showing that the expression of PRMT5 was high in AML-M5 patients, and the expression of PRMT was significantly higher in recurrent patients than that in other patients, indicating that the overexpression of PRMT5 was associated with the recurrence of AML (Figure 1).