We used Kaplan-Meier analysis to obtain the relations between these hub genes and lung cancer prognosis and found that the median survival time of the group with high expression of CDC20, CENPU, CHEK1, DTL, KIF14, MCM4, NCAPG2, NEK2, and FOXM1 is significantly shorter than that of the group with low expression of these genes. The gene discussed is CHEK1; the disease is lung cancer.